Endocrine Abstracts

Androgen, a key endocrine factor that drives normal prostate gland growth, is implicated in the progression of prostate cancer and benign prostate hyperplasia. However, failure to adapt androgen ablation therapy for the treatment of prostatic diseases cast doubts on our understanding of androgen role in the regulation of normal and abnormal prostate gland growth. This study was conducted to gain further insight into the role of androgen in maintaining a balanced prostatic cell...

The aim of this study was to evaluate the effect of testosterone treatment on the pattern of prostate cells proliferation and differentiation and their correlation with transforming growth factor-beta expression. Prostate gland development was compared in intact immature dogs with testosterone treated immature dogs for one month. Proliferation and differentiation pattern of prostatic cells were assessed by histological and immunohistological localization of proliferating cell ...